Clinical Trials.gov has listed a relatively new trial for constipation in Parkinson's and we provide the details below.
A Phase 2 Study to Evaluate the Safety and Efficacy of RM-131 in Patients With Parkinson's Disease & Chronic Constipation (MOVE-PD)
"The purpose of this study, called MOVE-PD, is to investigate how individuals with Parkinson's disease (PD) and chronic constipation (CC) respond to RM-131 as compared to placebo. The study will look at how well RM-131 affects the frequency of spontaneous bowel movements over a 14-day period. The study will also evaluate the safety and tolerability of the study drug and evaluate whether the study drug relieves the uncomfortable GI symptoms related to chronic constipation in patients who are unsatisfied with other therapies they have tried for constipation."
The mechanism of action for RM-131 is to bind to the growth hormone secretagogue
(GHS) 1a receptor and potentially activate GH secretion, increases food intake, Increases fat, increase gastrointestinal motility, and possibly even act as an anti-inflammatory.
The topic of constipation is so commonly searched on our website that we thought it important to let people know there is a new drug in trial that is promising. Our full Parkinson's disease treatment tips for constipation have been previously posted on the Parkinsonsecrets.com blog. Recently another drug Amityza has been useful for some Parkinson's disease constipation related issues.